You don't need to delete anyone to stop sending to them. AFRUS already leaves out of your sends people with a Hard Bounce (an address that doesn't exist), people who unsubscribed and people whose email is disabled. People with a Soft Bounce (a temporary problem) keep receiving emails. Labels are shown as they appear in the Spanish version of the console.
No. Deleting a person also deletes their donations, subscriptions and whole history.